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Joined 1 year ago
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Cake day: June 16th, 2023

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  • Thanks for that.

    Lack of blinding is a serious issue for subjective outcomes but blinding when treatment effects are obvious to both intervention and control groups is dishonest (Pharma does it all the time to make their trials look more credible than they are).

    Open label is the norm for cancer trials for exactly this reason. It is important to consider the biases that may arise, in subjective endpoints especially. But it is ludicrous to dismiss research on this basis alone. We can’t randomise 12 year olds to become lifetime smokers or not, let alone use placebo controls, but we do know that smoking kills. It’s just a bit more complicated to prove it when perfectly designed RCTs are not possible.




  • Your post has appeared in the wrong sub but the pressure vessel absolutely was jerry-rigged and the viewport wasn’t up to the job: A whistleblower raised safety concerns about OceanGate’s submersible in 2018. Then he was fired.

    The report detailed “numerous issues that posed serious safety concerns,” according to the filing. These included Lochridge’s worry that “visible flaws” in the carbon fiber supplied to OceanGate raised the risk of small flaws expanding into larger tears during “pressure cycling.” These are the huge pressure changes that the submersible would experience as it made its way and from the deep ocean floor. He noted that a previously tested scale model of the hull had “prevalent flaws.”

    A day after filing his report, Lochridge was summoned to a meeting with Rush and company’s human resources, engineering and operations directors. There, the filing states, he was also informed that the manufacturer of the Titan’s forward viewport would only certify it to a depth of 1,300 meters due to OceanGate’s experimental design. The filing states that OceanGate refused to pay for the manufacturer to build a viewport that would meet the Titan’s intended depth of 4,000 meters. The Titanic lies about 3,800 meters below the surface.



  • Voat died because it was landed with a big chunk of the toxicity ejected from reddit. This isn’t the same thing at all.

    The risk to the Fediverse from huge commercial players is described well here: How to Kill a Decentralised Network (such as the Fediverse)

    In 2013, Google realised that most XMPP interactions were between Google Talk users anyway. They didn’t care about respecting a protocol they were not 100% in control. So they pulled the plug and announced they would not be federated anymore. And started a long quest to create a messenger, starting with Hangout (which was followed by Allo, Duo. I lost count after that).

    As expected, no Google user bated an eye. In fact, none of them realised. At worst, some of their contacts became offline. That was all. But for the XMPP federation, it was like the majority of users suddenly disappeared. Even XMPP die hard fanatics, like your servitor, had to create Google accounts to keep contact with friends. Remember: for them, we were simply offline. It was our fault.

    And it’s not an accident:

    What Google did to XMPP was not new. In fact, in 1998, Microsoft engineer Vinod Vallopllil explicitly wrote a text titled “Blunting OSS attacks” where he suggested to “de-commoditize protocols & applications […]. By extending these protocols and developing new protocols, we can deny OSS project’s entry into the market.”

    Microsoft put that theory in practice with the release of Windows 2000 which offered support for the Kerberos security protocol. But that protocol was extended. The specifications of those extensions could be freely downloaded but required to accept a license which forbid you to implement those extensions. As soon as you clicked “OK”, you could not work on any open source version of Kerberos. The goal was explicitly to kill any competing networking project such as Samba.

    This anecdote was told Glyn Moody in his book “Rebel Code” and demonstrates that killing open source and decentralised projects are really conscious objectives. It never happens randomly and is never caused by bad luck.







  • How hydrogen is transforming these tiny Scottish islands

    Scotland’s Orkney Islands produce more clean energy than their inhabitants can use. Their next step? Hydrogen.

    Hydrogen is not free of problems: it degrades metal, leaks above a very low level have the potential to negate the environmental benefits, and it’s not particularly efficient because of the cost of compression. And Green hydrogen (which is more like a battery than a fuel) risks providing Big Carbon with a new excuse to pollute with their multi-coloured array of non-Green hydrogens (which are filthy fuels, nothing like a battery).

    But I’m not at all convinced about nuclear providing better answers than renewables. It takes decades for a new nuclear plant to come online, the same money invested in renewables starts yielding benefits immediately. And the problem of disposing of nuclear waste is not yet solved.